Silica Metal scavenger 硅基金属消除剂
Many chemical reactions, such as coupling reactions (Suzuki, Heck, Stille, Sonogashira, etc), ring closing metathesis (RCM), and hydrogenation, still require the use of metal catalysts, which can result in soluble metal contamination. In the case of active pharmaceutical ingredient (API) development, the metal catalyst must be removed to a regulated level. Purification of the API from remaining metal by traditional methods (chromatography, activated carbon, distillation, recrystallisation, ultrafiltration, or reverse osmosis) often leads to problems such as high costs, time consuming, low efficiency, and API losses.
许多化学反应，例如偶联反应（Suzuki, Heck, Stille, Sonogashira, 等），关环复分解反应（RCM），以及氢化，都需要用到金属催化剂，这些催化剂残留会造成金属污染。在API的开发过程中，金属催化剂的残留必须达到一定数值。采用传统方法纯化API（色谱，活性炭，蒸馏，重结晶，超滤，或者反渗透）通常会带来如下问题，高成本，费时，低效，以及产品损失。
Chiral Chemistry has developed an efficient alternative: Silica Metal Scavengers. These scavengers are made with high purity silica gel which does not suffer from polymers' shortcomings, (e.g., limited choice of solvents, excessive swelling, extensive washings, poor selectivity, and static charge). Our production line provides various efficient scavengers available for different metals such as Pd, Pt, Sn, Ru, Rh, Ni, Cr, etc.
我们开发了一个有效的替代办法：硅基金属消除剂。这类消除剂采用高纯硅胶作为原料，从而比聚合物有更多优势，聚合物有多种缺点（例如，有限的溶剂选择性，溶胀，额外的洗脱，低选择性，以及带有静电）。我们的产品线提供多种有效的金属消除剂，可以高效去除不同中类的金属，例如Pd，Pt，Sn，Ru，Rh，Ni，Cr，等。
| 产品名称 | Catalog Number | 结构 | 适用于 |
| Silica Thiol |
Ms001 |  |
Ag, Cu, Hg, Pd(0), Pd(II), Rh(I), Rh(II), Ru(IV) |
| Silica Amine |
Ms002 |  |
Cd, Pt, Rh(I), Rh(II) |
| Silica Diamine |
Ms003 |  |
Pd(0), Pd(II), Pt, Rh(I), Rh(II) |
| Silica Triamine |
Ms004 |  |
Pb, Pd(0), Pd(II), Pt |
| Silica TAAcONa |
Ms005 |  |
Cr, Co, Fe, Ni, Rh(II), Rh(III), Sn, Zn |
| Silica DMT |
Ms006 |  |
Ni , Pd(0), Pd(II), Pt, Rh(I), Rh(II), Ru(II), Ru(IV) |